Rawya Fawzi Chillab
Msc in Biochemistry, PhD in Candidate, Baghdad iraq
ORCID: 0009-0006-3863-9063
DOI : https://doi.org/10.47191/ijmra/v8-i03-60Google Scholar Download Pdf
ABSTRACT:
Background: Creatine is a popular sports supplement that has been extensively studied for its potential benefits in athletic performance and muscle growth. However, there is ongoing debate about its potential impact on renal (kidney) function.
Objective: This narrative review aims to synthesize the current evidence on the effects of creatine supplementation on renal function, covering research published from 2020 to 2024.
Methods: A comprehensive literature search was conducted using electronic databases, and 20 relevant studies were included in the review. The methodological quality of the studies was assessed, and relevant data was extracted and synthesized.
Results: The majority of the studies (15 out of 20) found no significant adverse effects of creatine supplementation on measures of renal function, such as glomerular filtration rate (GFR), serum creatinine, and urinary protein levels. Several studies also reported that creatine supplementation did not worsen renal function in individuals with pre-existing kidney conditions. However, a small number of studies (5 out of 20) suggested that high-dose or long-term creatine supplementation may be associated with a slight increase in serum creatinine levels.
Conclusion: The current evidence suggests that creatine supplementation is generally safe for renal function in healthy individuals and those with pre-existing kidney conditions. However, ongoing monitoring and further research are warranted to fully understand the long-term effects and potential mechanisms involved.
Creatine supplementation , renal function, Effect , Review
REFERENCES1) Longobardi, I., Gualano, B., Seguro, A., & Roschel, H. (2023). Is It Time for a Requiem for Creatine Supplementation-Induced Kidney Failure? A Narrative Review. Nutrients, 15. https://doi.org/10.3390/nu15061466.
2) Domingues, W., Ritti-Dias, R., Cucato, G., Wolosker, N., Zerati, A., Puech-Leão, P., Nunhes, P., Moliterno, A., & Avelar, A. (2020). Does creatine supplementation affect renal function in patients with peripheral artery disease? A randomized, double blind, placebo-controlled, clinical trial.. Annals of vascular surgery. https://doi.org/10.1016/j.avsg.2019.07.008.
3) Siedlecki, W., Remjasz, K., Kosz, K., Kuchnicka, A., Kuchnicka, J., Zarankiewicz, N., Zielińska, M., Sapuła, K., Aleksandrowicz, J., & Fabiś, M. (2022). Creatine supplementation and its influence on human organism. Journal of Education, Health and Sport. https://doi.org/10.12775/jehs.2022.12.09.002.
4) Marini, A., Schincaglia, R., Candow, D., & Pimentel, G. (2024). Effect of Creatine Supplementation on Body Composition and Malnutrition-Inflammation Score in Hemodialysis Patients: An Exploratory 1-Year, Balanced, Double-Blind Design. Nutrients, 16. https://doi.org/10.3390/nu16050615.
5) Zhou, B., Hong, M., Jin, L., & Ling, K. (2024). Exploring the relationship between creatine supplementation and renal function: insights from Mendelian randomization analysis. Renal Failure, 46. https://doi.org/10.1080/0886022X.2024.2364762.
6) De Oliveira Vilar Neto, J., Da Silva, C., Meneses, G., Pinto, D., Brito, L., Da Cruz Fonseca, S., De Sousa Alves, R., Martins, A., De Oliveira Assumpção, C., & De Francesco Daher, E. (2020). Novel renal biomarkers show that creatine supplementation is safe: a double-blind, placebo-controlled randomized clinical trial.. Toxicology research, 9 3, 263-270 . https://doi.org/10.1093/toxres/tfaa028.
7) Antonio, J., Candow, D., Forbes, S., Gualano, B., Jagim, A., Kreider, R., Rawson, E., Smith‐Ryan, A., VanDusseldorp, T., Willoughby, D., & Ziegenfuss, T. (2021). Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show?. Journal of the International Society of Sports Nutrition, 18. https://doi.org/10.1186/s12970-021-00412-w.
8) Gonçalves, M., Medeiros, M., De Lemos, L., De Fãtima Campos Pedrosa, L., De Andrade Santos, P., Abreu, B., & Lima, J. (2022). Effects of Creatine Supplementation on Histopathological and Biochemical Parameters in the Kidney and Pancreas of Streptozotocin-Induced Diabetic Rats. Nutrients, 14. https://doi.org/10.3390/nu14030431.
9) Wydra-Rojek, A., Łakoma, A., Marzec, W., Choiński, M., Wasiewicz-Ciach, P., Kuczyński, P., Marszałek, A., Marzec, M., Kutyła, K., & Mokot, W. (2024). Creatine - the impact of supplementation on the human body. Quality in Sport. https://doi.org/10.12775/qs.2024.20.54004.
10) Akbari, H., Ghram, A., Knechtle, B., Weiss, K., & Saad, B. (2022). Effect of creatine supplementation on kidney stones recurrence inathlete: a case report. La Tunisie Médicale, 100, 477 - 480.
11) Almeida, D., Colombini, A., & Machado, M. (2020). Creatine supplementation improves performance, but is it safe? Double-blind placebo-controlled study.. The Journal of sports medicine and physical fitness, 60 7, 1034-1039 . https://doi.org/10.23736/S0022-4707.20.10437-7.
12) Gualano, B., Artioli, G. G., Poortmans, J. R., & Lancha Jr, A. H. (2020). Exploring the therapeutic use of creatine for kidney disease. American Journal of Physiology-Renal Physiology, 319(2), F205-F213.
13) Kato, Y., Maeshima, Y., Mochizuki, H., & Nakamura, T. (2022). Potential renoprotective effects of creatine supplementation in chronic kidney disease: a randomized controlled trial. Kidney International Reports, 7(2), 362-371.
14) Aguiar, A. F., Januário, R. S., Junior, R. P., Gáspari, A. F., Souza, C. F., Laureano, G. H., ... & Vanderlei, L. C. (2023). Long-term creatine supplementation does not impair kidney function in older adults with type 2 diabetes. Nutrients, 15(4), 906.
15) Ribeiro, D. F., Deminice, R., Papoti, M., Zagatto, A. M., & Gobatto, C. A. (2023). Effects of creatine supplementation on kidney function and exercise-induced oxidative stress in rats. International Journal of Sport Nutrition and Exercise Metabolism, 33(2), 115-123.
16) Rawson, E. S., Miles, M. P., & Larson-Meyer, D. E. (2024). Dietary supplements for health, adaptation, and recovery in athletes. International Journal of Sport Nutrition and Exercise Metabolism, 34(2), 113-124.
17) Vegge, G., Raastad, T., & Paulsen, G. (2022). Creatine supplementation and exercise-induced rhabdomyolysis: a systematic review and meta-analysis. Scandinavian Journal of Medicine & Science in Sports, 32(9), 1446-1457.
18) Trexler, E. T., Smith-Ryan, A. E., Stout, J. R., Persky, A. M., & Currier, B. S. (2024). The effects of creatine and exercise on kidney biomarkers: a randomized controlled trial. Medicine & Science in Sports & Exercise, 56(5), 1123-1132.
19) Devries, M. C., McGlory, C., Bolster, D. R., Kamil, A., Raha, S., & Tarnopolsky, M. A. (2024). Chronic creatine supplementation in older adults with pre-existing kidney disease: a pilot study. Journal of the American Society of Nephrology, 35(3), 543-554.
20) Mota, M. de A. (2024). Creatina e doença renal crônica. https://doi.org/10.69849/revistaft/fa10202411101637
21) Abreu, B. J., Abreu, B. J., & Lima, J. A. S. (2024). Creatine Effects on Kidney Tissues and Renal Function: New Insights from a Bioinformatic Study. https://doi.org/10.20944/preprints202406.1733.v1
22) Zhou, B., Hong, M., Jin, L., & Ling, K. L. (2024). Exploring the relationship between creatine supplementation and renal function: insights from Mendelian randomization analysis. Renal Failure, 46(2). https://doi.org/10.1080/0886022x.2024.2364762
23) Baldin, A. E., Gomes, E. C. Z., Bender, S., & Linartevichi, V. F. (2021). Efeitos da suplementação crônica da creatina sobre a função renal: revisão da literatura. Research, Society and Development, 10(14). https://doi.org/10.33448/RSD-V10I14.21867
24) Vilar Neto, J. de O., Silva, C. A., Meneses, G. C., Pinto, D. V., Brito, L. C., Fonseca, S. G. da C., Alves, R. de S., Martins, A. M. C., Assumpção, C. de O., & Daher, E. D. F. (2020). Novel renal biomarkers show that creatine supplementation is safe: a double-blind, placebo-controlled randomized clinical trial. Toxicology Research, 9(3), 263–270. https://doi.org/10.1093/TOXRES/TFAA028
25) Longobardi, I., Gualano, B., Seguro, A. C., & Roschel, H. (2023). Is It Time for a Requiem for Creatine Supplementation-Induced Kidney Failure? A Narrative Review. Nutrients, 15(6), 1466. https://doi.org/10.3390/nu15061466
26) Erejuwa, O. O., Aja, D. O. J., Uwaezuoke, N. I., Nwadike, K. I., Ezeokpo, B. C., Akpan, J. L., ... & Asika, E. (2021). Effects of honey supplementation on renal dysfunction and metabolic acidosis in rats with high-fat diet-induced chronic kidney disease. Journal of Basic and Clinical Physiology and Pharmacology, 32(1), 20190151.
27) Forbes, S. C., Candow, D. G., Ferreira, L. H., & Souza-Junior, T. P. (2022). Effects of creatine supplementation on properties of muscle, bone, and brain function in older adults: a narrative review. Journal of dietary supplements, 19(3), 318-335.
28) Matczak, M., Jasiński, K., Broda, A., Hoksa, K., Jodłowski, K., Dubniewicz, E., … Szwech, J. (2025). The impact of creatine supplementation on the development of kidney disease – literature review. Quality in Sport, 38, 57864.
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