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Volume 06 Issue 11 November 2023

Identification of Calcium and Magnesium in Medicine Using Plasma Laser Spectroscopy
1Heri Sugito, 2Ali Khumaeni, 3Inaini Maskhanatul Fuadah
1,2,3Department of Physics, Faculty of Science and Mathematics, Diponegoro University, Semarang, Indonesia 50275
DOI : https://doi.org/10.47191/ijmra/v6-i11-39

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ABSTRACT:

The identification of magnesium (Mg) in pharmaceutical products was carried out using LIPS (Laser-Induced Plasma Spectroscopy). The lasers used in the research were Nd: YAG laser and CO2 laser. The sample used was a supplement tablet. The laser beam is directed and focused by a convex lens on the sample. The plasma beam is induced on the sample surface. The sharp and high-intensity emission spectrum detected using the Nd: YAG laser indicates the presence of Calcium (Ca) and Magnesium (Mg) in the sample. The results obtained were then compared with sample testing using a CO2 laser. The results of the Mg spectrum intensity were much higher using a CO2 laser.

KEYWORDS:

LIPS, Nd: YAG, Magnesium, Calsium

REFERENCES
1) Porta, R., et al. (2016). Flow Chemistry: Recent Developments in the Synthesis of Pharmaceutical Products. Organic Process Research & Development 20(1): 2-25.

2) Wang, J., Wang, S., Ge, X., and Zhang, M., 2021. Authentication of American Ginseng ( Panax quinquefolius L) from Different Origins by Linear Discriminant Analysis of Multi‑Elements. European Food Research and Technology, 247(10), 2657–2666.

3) Lokhande, R., Singare, P., and Andhale, M., 2010. Study on Mineral Content of some Ayurvedic Indian Medicinal Plants by Instrumental Neutron Activation Analysis and AAS Techniques. Health Science Journal, 4(3), 157–168.

4) Nicolodelli, G., Senesi, GS, Oliveira Perazzoli, IL, Marangoni, BS, De Melo Bentines, V., and Milori. 2016. Double Pulse Laser Induced Breakdown Spectroscopy: a Potential Tool for the Analysis of Contaminants and Macro/Micronutrients in Organic Mineral Fertilizers. Science of the Total Environment, 565, 1116-1123.

5) Khumaeni, A., Hartadi, BS, Wardaya, AY, Sugito, H., and Budi, WS, 2020. Identification and Analysis of Major Elements in Indonesian Herbal Medicine using Laser-Induced Plasma Spectroscopy. Rasayan Journal of Chemistry, 13(2), 898–902.

6) Destriati, E., Marpaung, MA, and Karnadi, I., 2020. Identification of Mercury Metal Content in Cosmetics Using Laser Induced Breakdown Spectroscopy (LIBS) Technique. Proceedings of the UNJ National Physics Seminar, December 2020.

7) Miziolek W, Palleschi V, Schechter, I.(2006). Laser-induced Breakdown Spectroscopy (LIBS), Fundamentals and Applications (Cambridge University Press, New York).

8) Cremers DA, and Radziemski LJ (2006). Handbook of Laser-Induced Breakdown Spectroscopy (John Wiley and Sons Ltd, Chichester).

9) Khumaeni, A., et al. (2010). A novel double-pulse laser plasma spectroscopic technique for H analysis in metal samples using transversely excited atmospheric-pressure CO2 laser-induced metastable He atoms. Optical Review 17(3): 285-289.

10) Ali Khumaeni, Zener Sukra Lie, Hideaki Niki, Yong Inn Lee, Kazuyoshi Kurihara, Motoomi Wakasugi, Touru Takahashi, and Kiichiro Kagawa, (2012). Comparative study of Nd: YAG laser-induced breakdown spectroscopy and transversely excited atmospheric CO2 laser-induced gas plasma spectroscopy on chromated copper arsenate preservative-treated wood. Appl. Opt. 51, B121-B129.

11) St-Onge L., Kwong E., Sabsabi M., Vadas E.B. (2002).Quantitative analysis of pharmaceutical products by laser-induced breakdown spectroscopy.Spectrochim. Acta BVolume 57, Issue 7, p. 1131-1140.

12) Khumaeni, A., et al. (2012). Emission Characteristics of Ca and Mg Atoms in Gas Plasma Induced by the Bombardment of Transversely Excited Atmospheric CO$_{2}$ Laser at 1 atm. Japanese Journal of Applied Physics 51: 082403.
Volume 06 Issue 11 November 2023

There is an Open Access article, distributed under the term of the Creative Commons Attribution – Non Commercial 4.0 International (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/), which permits remixing, adapting and building upon the work for non-commercial use, provided the original work is properly cited.


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