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Volume 05 Issue 05 MAY 2022

Relationships Between the Achieved Target Levels of LDL Cholesterol and the State of Various Types of LV EF in Patients with Coronary Artery Disease and Type 2 Diabetes
1Mukharram A.Musaeva, 2Dinara A.Parpibaeva, 3Muborak S.Salaeva, 4Nargiza D.Salimova
1Assistant of the simulation training department of the Tashkent Medical Academy, Tashkent, Uzbekistan
2Doctor of Medical Sciences, Associate Professor, Head of the Department of Simulation training, Tashkent Medical Academy, Tashkent, Uzbekistan
3Candidate of medical sciences, Associate Professor of the Department of Simulation training, Tashkent Medical Academy, Tashkent, Uzbekistan
4Candidate of medical sciences, Associate Professor of the Department of Simulation training, Tashkent Medical Academy, Tashkent, Uzbekistan
DOI : https://doi.org/10.47191/ijmra/v5-i5-13

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ABSTRACT:

Today, diabetes mellitus is one of the most powerful risk factors for the development of cardiovascular diseases and its complications. [1] In 50% of patients with type 1 diabetes and in 80% of people with type 2 diabetes, early disability and premature death are recorded due to cardiovascular complications. People with diabetes are often at risk for strokes, heart attacks, and high blood pressure. In this regard, the main strategy for the treatment of patients with diabetes is to prevent the development of cardiovascular complications, which includes strict control of glycemia, blood pressure, as well as antiplatelet and lipid-lowering therapy.

Despite the fact that strict glycemic control alone does not reduce the risk of myocardial infarction and mortality from it, most epidemiological and pathophysiological studies indicate a worse prognosis and a higher incidence of cardiovascular complications in chronic hyperglycemia. The use of a fixed combination of sitagliptin / metformin is one of the preferred options in the treatment of type 2 diabetes in patients with a high risk of cardiovascular disease due to the presence of type 4 dipeptidyl peptidase inhibitors of cardio protective effects. In this paper, changes in the lipid spectrum in patients with ischemic heart disease and type 2 diabetes mellitus with varying degrees of cardiac output are related to the number of years the patient has had diabetes mellitus, sitagliptin / metformin and statin drugs changes depending on the dose are highlighted.

KEYWORDS:

dipeptidyl peptidase-4 inhibitors, metformin, type 2 diabetes mellitus, heart failure, average ejection fraction, preserved ejection fraction, lipid spectrum, statin.

REFERENCES

1) Diabetes mellitus and cardiovascular diseases // Edited by Ametov A.S., Kurochkin I.O.

2) Ametov A.S., Pakus E.N. Efficacy and safety of the combination of metformin and sitagliptin in the treatment of patients with type 2 diabetes mellitus with obesity // Diabetes Mellitus 2010. No. 3. C. 62–65.

3) Algorithms of specialized medical care for patients with diabetes mellitus / Edited by I.I. Dedova, M.V. Shestakova, A.Yu. Mayorova. – 9th edition (updated). – M.; 2019. P. 214. DOI: 10.14341/DM221S1

4) Rustamova M.T., Salaeva M.S., Salimova N.D., Nurmatov D.Kh. Influence of risk factors for the development of renal dysfunction in patients with stable angina on the background of type II diabetes mellitus // Bulletin of the Association of Physicians of Uzbekistan, Tashkent. 2020. S. 16-19

5) Kubota A, Maeda H, Kanamori A, Matoba K, Jin Y, Minagawa F, et al. Pleiotropic effects of sitagliptin in the treatment of type 2 diabetes mellitus patients. J Clin Med Res 2012; 4:309-13.

6) Sesti G, Avogaro A, Belcastro S, Bonora BM, Croci M, Daniele G, et al. . Ten years of experience with DPP-4 inhibitors for the treatment of type 2 diabetes mellitus. Acta Diabetol. (2019) 56:605–17. 10.1007/s00592-018-1271-3

7) Gallwitz B. Novel therapeutic approaches in diabetes. Endocr Dev. (2016) 31:43–56. 10.1159/000439372

8) Deacon CF, Holst JJ. Dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes: comparison, efficacy and safety. Expert Opin Pharmacother. (2013) 14:2047–58. 10.1517/14656566.2013.824966

9) Gerich JE. Contributions of insulin-resistance and insulin-secretory defects to the pathogenesis of type 2 diabetes mellitus. Mayo Clinic Proc. (2003) 78:447–56. 10.4065/78.4.447

10) Creutzfeldt W. The incretin concept today. Diabetology. (1979) 16:75–85. 10.1007/BF01225454

11) Nauck MA, Meier JJ. Incretin hormones: their role in health and disease. Diabetes Obes Metab. (2018) 20(Suppl 1):5–21. 10.1111/dom.13129

12) Sesti G, Avogaro A, Belcastro S, Bonora BM, Croci M, Daniele G, et al. . Ten years of experience with DPP-4 inhibitors for the treatment of type 2 diabetes mellitus. Acta Diabetol. (2019) 56:605–17. 10.1007/s00592-018-1271-3

Volume 05 Issue 05 MAY 2022

There is an Open Access article, distributed under the term of the Creative Commons Attribution – Non Commercial 4.0 International (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/), which permits remixing, adapting and building upon the work for non-commercial use, provided the original work is properly cited.


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