1Randa Masood Elsehati, 1Abeer Hussein Amer, 2Eslam Osama Najem, 2Wael Abdel-Razek AlFarjani, 2Aisha Khamis AlArfi, 2Mawada Mohamed Alshaykhi, 2Sufyan Mohammed AlGhuwail
1Department of Histology, Faculty of Medicine, University of Benghazi, Benghazi, Libya.
2Department of Cytotechnology, Faculty of Biomedical Sciences, University of Benghazi, Benghazi, Libya.
DOI : https://doi.org/10.47191/ijmra/v8-i02-26Google Scholar Download Pdf
ABSTRACT:
Background: Breast cancer is the second most common cancer worldwide, the most frequent among women, and the leading cause of cancer death in females globally.
Aim: This study aims to examine the pattern of breast cancer in patients who presented to the oncology department at Benghazi Medical Center (BMC) from January 1, 2020, to December 31, 2023.
Patients and Methods: The study is a descriptive, retrospective cross-sectional analysis. Data were collected from 100 breast cancer patient records at BMC, selected from a total of 1,472 registered cases. Patients included in the study had confirmed diagnoses of breast cancer by histopathology. (Adding pictures from Al Noon Laboratory).
Results: Out of 100 breast cancer patients registered at the oncology department, 90 were from Benghazi, and 10 were from outside the city. The majority (45%) were aged 40 to 49. Invasive ductal carcinoma was the most common type, found in 89% of cases. Among these, 47% were in Grade II, and 56% were in Stage II. Positive estrogen receptor status was observed in 93% of cases, while 53% had positive progesterone receptor status. Additionally, 78% of patients were negative for human epidermal growth factor receptor 2 (HER2), and 30% had a Ki-67 level between 10-25%.
Conclusions: Most breast cancer cases at BMC were from Benghazi. The highest frequency was in the 40-49 age group, with most cases being invasive ductal carcinoma, HER2 negative, ER positive, and PR positive, and predominantly in Grade II and Stage II.
implementation, policy, Character education, higher education.
REFERENCES1) Ali, A. Ahmad, M. Javeed, N. Ijaz, M. Khan, MM. Khattak, R. (2017). Clinical and histopathological parameters of the patients with breast cancer from North West Pakistani Population. JIIMC; 12:208-12.
2) Asiri, S. Asiri, A. Ulahannan, S. (2017) Incidence Rates of Breast Cancer by Age and Tumor Characteristics Among Saudi Women: Recent Trends. Cureus 12(1): e6664.
3) Bray, F. McCarron, P. Parkin, DM. (2004). The changing global patterns of female breast cancer incidence and mortality. Breast Cancer Res;6:229-39.
4) Beral, V. (2003): Breast cancer and hormone-replacement therapy in the Million Women Study. Lancet. 362: 419-427.
5) Bakkali, H. Marchal, C. Lesur-Schwander, A. Verhaeghe, JL. (2003). Le cancer du sein chez la femme de 30 ans et moins. [Breast cancer in women thirty years old or less] Cancer Radiotherapie.;7:153–159. French.
6) Boder, JM. Elmabrouk. Abdalla, FB. Elfageih, MA. Abusaa, A. Buhmeida, A. Collan, Y. (2011). Breast cancer patients in Libya: Comparison with European and central African patients. Oncol Lett; 2:323-30.
7) DeSantis, C. Ma, J. Bryan, L. Jemal, A. (2014). Breast cancer statistics, 2013. CA Cancer J Clin; 64:52-62.
8) Engl J, N. (2006). Estrogen carcinogenesis in breast cancer .19;354(3):270-82.
9) El Mistiri, M. Verdecchia, A. Rashid, I. El Sahli, N. El Mangush, M. Federico, M. (2003): Cancer incidence in eastern Libya: the first report from the Benghazi Cancer Registry. Int J Cancer 2007; 120: 392.
10) Eramah Elarabi, A. Ermiah. (2013) Libyan Breast Cancer: Health services andbiology. Diagnosis delay and prognostic value of DNA ploidy, S-phase fraction, and Ki-67 and Bcl-2 immunohistochemistry Res; 32: 3485-3494.
11) Gao, Q. Neuhausen, S. Cummings, S. Luce, M. and Olopade, O. I. (1997), "Recurrent germ-line BRCA1 mutations in extended African American families with early-onset breast cancer American Journal of Human Genetics, View at: vol. 60, no. 5, pp. 1233.
12) Gusbil, Eman. Elgriw1, Nada. Zalmat2, Shiaa. Alemamı, Hafsa. Khalil2, Sumia.Gusbi3, Mokhtar. Elhamadi3, Miluda. Benyasaad2, Taha. Enattahl, Nabil. Elzagheid, Adarn. (2018) Breast cancer in western part of Libya: Pattern and management P: 65-71 (2003-2018).
13) Moore, K. L. and Dalley, A. F.: Clinically oriented anatomy, 5th edition, (2006), p. 105 – 111.
14) Malvia, S. Bagadi, SA. Dubey, US. Saxena, S. (2017). Epidemiology of breast cancer in Indian women. Asia Pac J Clin Oncol: 13:289-95.
15) Maalej M. Hentati D. Messai T, et al (2008). Breast cancer in Tunisia in 2004: a comparativeclinical and epidemiological study. Ball Cancer, 95, 5-9.
16) Nadia, M. Iman, G. Iman, A. (2007). Cancer pathology registry 2003–2004 and time trend analysis. NCI; Cairo. Journal of the Egyptian National CancerInstitute 19(2):158-62
17) Nagata, C. Kawakami, N. Shimizu, H. (1997). Trends in the incidence rate and risk factors for breast cancer in Japan. Breast Cancer Res Treat. ; 44:75–82.
18) Lane-Claypon, JE.(1926): A Further Report on Cancer of the Breast, with Special Reference to its Associated Antecedent Conditions, London: HMSO, Report on Public Health and Medical Subjects No. 32
19) Pompe-Kirn, V. Japelj, B. Primic-Zakelj, M. (2000). Future trends in breast, cervical, lung, mouth and pharyngeal cancer incidence in Slovenia. Cancer Causes Control. ;11:309–18.
20) Parkin, D. Fernandez, G. (2006). Use of statistics to assess the global burden of breast cancer. Breast J.; 12:S70–S80
21) Pike, MC. Krailo, MD. Henderson, BE. Casagrande, JT. Hoel, DG. (1983): "Hormonal risk factors, breast tissue age' and the age-incidence of breast cancer. Nature., 303: 767-70.
22) Reeder, JG. Vogel, VG. (2008). "Breast cancer prevention". Advances in Breast Cancer
Management, Second Edition. Cancer Treatment and Research. 141. pp. 149-64
23) Rosai, J. (2011) Breast. In: Rosai and Ackerman's Surgical Pathology. 10th ed. St. Louis: Mosby. p.1659-770.
24) Ravichandran, K. Al-Zahrani, AS. (2009) Association of reproductive factors with theincidence of breast cancer in Gulf Cooperation Council countries. East Mediterr Health J.:15:612-21.
25) Sauter ER. Reliable Biomarkers to Identify New and Recurrent Cancer. Eur J Breast Health 2017:13:1627.
26) Stapleton, JM. Mullan, PB. Dey, S. Hablas, A. Gaafar, R. Seifeldin, IA. Banerjee, M. Soliman, AS.(2011). Patient-mediated factors predicting early and late-stage presentation of breast cancer in Egypt. Psychooncology, 20: 532-537
27) Soliman, NA. Yussif, SM. (2016). Ki-67 as a prognostic marker according to breast cancer molecular subtype. Cancer Biol Med; 13:496-504.
28) Torre, LA. Bray, F. Siegel, RL. Ferlay, J. Lortet-Tieulent, J. Jemal, A.(2015). Global cancer statistics, 2012. CA Cancer J Clin;65:87-108
29) Wiliams C, Olopade O, Falkson C(2006), editors. Breast cancer in women of African descent. Springer, Netherlands :P.394/384 .
Volume 08 Issue 02 February 2025

There is an Open Access article, distributed under the term of the Creative Commons Attribution – Non Commercial 4.0 International (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/), which permits remixing, adapting and building upon the work for non-commercial use, provided the original work is properly cited.
Our Services and Policies
Authors should prepare their manuscripts according to the instructions given in the authors' guidelines. Manuscripts which do not conform to the format and style of the Journal may be returned to the authors for revision or rejected.
The Journal reserves the right to make any further formal changes and language corrections necessary in a manuscript accepted for publication so that it conforms to the formatting requirements of the Journal.
International Journal of Multidisciplinary Research and Analysis will publish 12 monthly online issues per year,IJMRA publishes articles as soon as the final copy-edited version is approved. IJMRA publishes articles and review papers of all subjects area.
Open access is a mechanism by which research outputs are distributed online, Hybrid open access journals, contain a mixture of open access articles and closed access articles.
International Journal of Multidisciplinary Research and Analysis initiate a call for research paper for Volume 08 Issue 02 (February 2025).
PUBLICATION DATES:
1) Last Date of Submission : 25 February 2025 .
2) Article published within a week.
3) Submit Article : editor@ijmra.in or Online
Why with us
1 : IJMRA only accepts original and high quality research and technical papers.
2 : Paper will publish immediately in current issue after registration.
3 : Authors can download their full papers at any time with digital certificate.
The Editors reserve the right to reject papers without sending them out for review.
Authors should prepare their manuscripts according to the instructions given in the authors' guidelines. Manuscripts which do not conform to the format and style of the Journal may be returned to the authors for revision or rejected. The Journal reserves the right to make any further formal changes and language corrections necessary in a manuscript accepted for publication so that it conforms to the formatting requirements of the Journal.