1Alyaa M. Ali, 2Anwar Shaqi Ajil
1Al-Nasiriyah Technical Institute Southern Technical University
2Department of community health / Technical Institute / Nassiriyah, Southern Technical University
DOI : https://doi.org/10.47191/ijmra/v7-i07-58Google Scholar Download Pdf
ABSTRACT:
Background:
The purpose of this investigation is to determine whether or not fungus belonging to the genus Candida can be found within atherosclerotic plaques and to examine various immunological and biochemical indices in patients with particular cardiac conditions who also harbour Candida spp. Specifically, here's what to do and how to do it: In order to determine if fungi were present in an atherosclerotic plaque, a specific test was performed.
Method:
Twenty autopsies revealed a total of 61 atherosclerotic plaques. In addition, 41 persons with atherosclerosis had their blood tested for TNF-α and IgG and IgM antibodies to Candida spp. There were a wide range of ages represented in this group, from 34 to 85 years old, with 28 men and 13 women.
Results:
The results showed that fungal species belonging to the genus Candida were present in 24.9% (10/41) of atherosclerotic plaques. Candida krusei and C. dubliniensis were the most common types of Candida identified, while occasionally C. tropicalis and C. albicans were discovered. None of the 41 patients tested positive for IgM, although 30 of them (73.1% of the total) did test positive for IgG. There were fewer IgG-negative patients (n=6) with TNF-α than IgG-positive patients (n=11), although the TNF-α levels in the former were significantly greater than those in the latter (511.7pg/ml, p <0.05). It was shown that the discrepancies between ASAT and ALT levels were much larger in patients who tested positive for Candida spp but negative for TNF-α.
Conclusion:
Candida fungus may contribute to atherosclerosis by inducing inflammation in the lining of blood vessels.
Candida albicans – Candida infection – fungal infections – heart disease
REFERENCES1) Sastry PS. Occult fungal infection is the underlying patogenic cause of atherogenesis. Med Hypotheses. 2004;63:671–674. [PubMed] [Google Scholar]
2) Akberov RF, Shafareyev AZ, Mihaylov MH. Progressing multifocal atherosclerosis: an etiology, clinical-radio diagnostics, modern aspects of treatment. Kazan: Ideal-Press publishing; 2008. [Google Scholar]
3) Kiyoshi K, Shingo Y, Miura NN, Horie S, Usui Y, Adachi Y, Yadomae T, Ohno N. Effect of CAWS, a mannoprotein-β-glican Complex of Candida albicans, on leukocyte, Endotelial Cell and Platelet Functions in vitro . Biol Pharm Bull. 2003;26:233–240. [PubMed] [Google Scholar]
4) Leroy O, Gangneux JP, Montravers P, Mira JP, Gouin F, Sollet JP, Carlet J, Reynes J, Rosenheim M, Regnier B, Lortholary O AmarCand Study Group. Epidemiology, Management and Risk Factor for Death of Invasive Candida Infections in Critical Care: A Multicenter, Prospective, Observational Study in Franse. Crit Care Med. 2009;37:1612–1618. [PubMed] [Google Scholar]
5) Wang CC, Lin SK, Tseng YF, Hsu CS, Tseng TC, Lin HH, Wang LY, Kao JH. Elevator of serum aminotransferase activity increases risk of carotid atherosclerosis in patients with non-alcoholic fatty liver disease. J GastroenterolHepatol. 2009;24:1411–1416. [PubMed] [Google Scholar]
6) Shiu B, Viira Y, Taker V, Fong I. Chlamidiapneumaniae (ChP), cytomegalovirus (C) and virus Herpes simplex (VHS) in an atherosclerosis of the carotid artery. Int Med Journal. 1998;2:136–138. [Google Scholar]
7) Vatutin NT, Chupina VA. Infection as the factor of development of the atherosclerosis and its complications. Cardiology. 2000;2:67–71. [Google Scholar]
8) Nurgeldiyeva MJ, Hojakuliyev BG, Muhammedov MB. Correlation of atherogenesis with an infection of Candida albicans. Int J ClinExp Med. 2014;7(8):2137-43. PMID: 25232398; PMCID: PMC4161558.
9) Muhlestein JB, Hammond EH, Carlquist JF, Radicke E, Thomson MJ, Karagounis LA, Woods ML, Anderson JL. Increased Indence of chlamydia species within the coronary arteries of patents with symptomatic atherosclerotic versus other forms of cardiovascular disease. J Am CollCardiol. 1996;7:1555–1561. [PubMed] [Google Scholar]
10) Mamtani S, Aljanabi NM, Gupta Rauniyar RP, Acharya A, Malik BH. Candida Endocarditis: A Review of the Pathogenesis, Morphology, Risk Factors, and Management of an Emerging and Serious Condition. Cureus. 2020;12(1):e6695. doi: 10.7759/cureus.6695. PMID: 32104631; PMCID: PMC7026878.
11) Nagi-Miura N, Harada T, Shinohara H, Kurihara K, Adachi Y, Ishida-Okawara A, Oharaseki T, Takahashi K, Naoe S, Suzuki K, Ohno N. Lethal and severe coronary arteritis in DBA/2 mice induced by fungal pathogen, CAWS, Candida albicans water-soluble fraction. Atherosclerosis. 2006;186:310–320. [PubMed] [Google Scholar]
12) Szkaradkiewich A, Bogaczy E, Ska-Staniewicz J, Torliński L, Wal M. Cytomegalovirus infection and atherosclerosis. Med SciMonit. 2002;8:104–7. [Google Scholar]
13) Masoumi O, Shahzadi M, Kordbacheh P, Zaini F, Mahmoudi S, Mahmoudi M, Bahreini H, Safara M, Mirhendi H. Detection of Fungal Elements in Atherosclerotic Plaques Using Mycological, Pathological and Molecular Methods. Iran J Public Health. 2015 Aug;44(8):1121-5. PMID: 26587476; PMCID: PMC4645732.
14) Yulish YI, Nagornaya NV. Chronic endocellular infections and cardiovascular pathology. Clinical Lectures. 2007:2. [Google Scholar]
15) Reshetnikov V, Malyutina SK, Nikitin YP. Frequency of the revealings of some infections in patients with an ischemic heart trouble. Clin Med. 2008;2:33–37. [Google Scholar]
16) Alekperov EZ, Nadjarov RN. Modern concepts of the inflammation role in an atherosclerosis. Cardiology. 2010;6:88–91. [PubMed] [Google Scholar]
17) Ivashkin VT. Cellular and molecular biology of the liver inflammation. Russ J GastroenterolHepatolColoproctol. 1998;5:13–17. [Google Scholar]
18) Marevichev MM, Jdanov VS, Galahanov IY. Atherosclerosis depending on alcohol intake in almost healthy men. Cardiovascular Therapy Prof. 2009;8(Suppl 1):226. [Google Scholar]
19) Taheri Sarvtin M, ZandParsa A, Kordbacheh P, Hashemi S, Mahmoudi M, Daie R, et al. (2014). Camparison of Oral Candida Flora in Patients with Coronary Atherosclerosis and Healthy People. ZJRMS, 16 (1): 40– 43. [Google Scholar] [Ref list]
20) 20-Campbell LA, Yaraei K, Van Lenten B, Chait A, Blessing E, Kuo CC, Nosaka T, Ricks J, Rosenfeld ME. The acute phase reactant response to respiratory infection with Chlamydia pneumoniae: implication for the patogenesis of atherosclerosis. Microbes Infect. 2010;12:598–606. [PMC free article] [PubMed] [Google Scholar]
21) Epstein SE, Zhou YF, Zhu J. Infection and atherosclerosis: emerging mechanistic paradigms. Circulation. 1999;100:e20–8. [PubMed] [Google Scholar]
22) Bayramova GR. Chronic relapsing vulvovaginal candidiasis: the diagnostic principles and therapy possibilities. Obstetrics Gynecology. 2008;6:64–66. [Google Scholar]
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