• editor@ijmra.in
  • ISSN[Online] : 2643-9875  ||  ISSN[Print] : 2643-9840

Volume 07 Issue 10 October 2024

Understanding the Connection between Vitamin D and Diabetes: A Narrative Review
Rawya Fawzi Chillab.
Msc in Biochemistry, Baghdad Iraq
ORCID: 0009-0006-3863-9063
DOI : https://doi.org/10.47191/ijmra/v7-i10-03

Google Scholar Download Pdf
ABSTRACT:

Diabetes is a persistent medical condition distinguished by elevated concentrations of glucose in the bloodstream. This condition has a global impact, impacting millions of individuals, and inadequate management can result in a range of complications. Despite the absence of a cure for diabetes, exercise and diet, among other lifestyle components, can significantly impact its management. Interest in the potential function of vitamin D in the prevention and management of diabetes has increased in recent years. This article aims to investigate the correlation between vitamin D and diabetes, elucidate the possible mechanisms underlying its impacts, and survey the existing scientific literature that substantiates its efficacy.

KEYWORDS:

Diabetes, Vitamin D, Correlation, Review

REFERENCES
1) Pittas, A., Lau, J., Hu, F., & Dawson-Hughes, B. (2007). The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. The Journal of clinical endocrinology and metabolism, 92 6, 2017-29 .

2) Mitri, J., Muraru, M., & Pittas, A. (2011). Vitamin D and type 2 diabetes: a systematic review. European Journal of Clinical Nutrition, 65, 1005-1015.

3) Zhang, M., Pan, G., Guo, J., Li, B., Qin, L., & Zhang, Z. (2015). Vitamin D Deficiency Increases the Risk of Gestational Diabetes Mellitus: A Meta-Analysis of Observational Studies. Nutrients, 7, 8366 - 8375.

4) Li, X., Liu, Y., Zheng, Y., Wang, P., & Zhang, Y. (2018). The Effect of Vitamin D Supplementation on Glycemic Control in Type 2 Diabetes Patients: A Systematic Review and Meta-Analysis. Nutrients, 10.

5) Rafiq, S., & Jeppesen, P. (2018). Is Hypovitaminosis D Related to Incidence of Type 2 Diabetes and High Fasting Glucose Level in Healthy Subjects: A Systematic Review and Meta-Analysis of Observational Studies. Nutrients, 10.

6) Chiu, K., Chu, A., Go, V., & Saad, M. (2004). Hypovitaminosis D is associated with insulin resistance and β cell dysfunction. The American Journal of Clinical Nutrition, 79, 820-825.

7) Pittas, A., Dawson-Hughes, B., Li, T., Dam, R., Willett, W., Manson, J., & Hu, F. (2006). Vitamin D and calcium intake in relation to type 2 diabetes in women.. Diabetes care, 29 3, 650-6 .

8) Palomer, X., González‐Clemente, J., Blanco-Vaca, F., & Mauricio, D. (2008). Role of vitamin D in the pathogenesis of type 2 diabetes mellitus. Diabetes, 10.

9) Kayaniyil, S., Vieth, R., Retnakaran, R., Knight, J., Qi, Y., Gerstein, H., Perkins, B., Harris, S., Zinman, B., & Hanley, A. (2010). Association of Vitamin D With Insulin Resistance and β-Cell Dysfunction in Subjects at Risk for Type 2 Diabetes. Diabetes Care, 33, 1379 - 1381.

10) Poel, Y., Hummel, P., Lips, P., Stam, F., Ploeg, T., & Simsek, S. (2012). Vitamin D and gestational diabetes: a systematic review and meta-analysis. European journal of internal medicine, 23 5, 465-9 .

11) Garbossa, S., & Folli, F. (2017). Vitamin D, sub-inflammation and insulin resistance. A window on a potential role for the interaction between bone and glucose metabolism. Reviews in Endocrine and Metabolic Disorders, 18, 243-258.

12) Delvin, E., Lambert, M., Levy, E., O'Loughlin, J., Mark, S., Gray‐donald, K., & Paradis, G. (2010). Vitamin D status is modestly associated with glycemia and indicators of lipid metabolism in French-Canadian children and adolescents. The Journal of nutrition, 140 5, 987-91 .

13) Reis, A., Hauache, O., & Velho, G. (2005). Vitamin D endocrine system and the genetic susceptibility to diabetes, obesity and vascular disease. A review of evidence. Diabetes & metabolism, 31 4 Pt 1, 318-25 .

14) Tepper, S., Shahar, D., Geva, D., & Ish-Shalom, S. (2016). Differences in homeostatic model assessment (HOMA) values and insulin levels after vitamin D supplementation in healthy men: a double‐blind randomized controlled trial. Diabetes, 18.

15) Jorde, R., Sollid, S., Svartberg, J., Schirmer, H., Joakimsen, R., Njølstad, I., Fuskevåg, O., Figenschau, Y., & Hutchinson, M. (2016). Vitamin D 20,000 IU per Week for Five Years Does Not Prevent Progression From Prediabetes to Diabetes. The Journal of clinical endocrinology and metabolism, 101 4, 1647-55 .

16) Mathieu, C., Gysemans, C., Giulietti, A., & Bouillon, R. (2005). Vitamin D and diabetes. Diabetologia, 48, 1247-1257.

17) Pilz, S., Kienreich, K., Rutters, F., Jongh, R., Ballegooijen, A., Grübler, M., Tomaschitz, A., & Dekker, J. (2013). Role of Vitamin D in the Development of Insulin Resistance and Type 2 Diabetes. Current Diabetes Reports, 13, 261-270.

18) Mattila, C., Knekt, P., Männistö, S., Rissanen, H., Laaksonen, M., Montonen, J., & Reunanen, A. (2007). Serum 25-hydroxyvitamin D concentration and subsequent risk of type 2 diabetes. Diabetes care, 30 10, 2569-70 .

19) Dutta, D., Mondal, S., Choudhuri, S., Maisnam, I., Reza, A., Bhattacharya, B., Chowdhury, S., & Mukhopadhyay, S. (2014). Vitamin-D supplementation in prediabetes reduced progression to type 2 diabetes and was associated with decreased insulin resistance and systemic inflammation: an open label randomized prospective study from Eastern India. Diabetes research and clinical practice, 103 3, e18-23.

20) Breslavsky, A., Frand, J., Matas, Z., Boaz, M., Barnea, Z., & Shargorodsky, M. (2013). Effect of high doses of vitamin D on arterial properties, adiponectin, leptin and glucose homeostasis in type 2 diabetic patients. Clinical nutrition, 32 6, 970-5 .

21) Lee, C., Iyer, G., Liu, Y., Kalyani, R., Bamba, N., Ligon, C., Varma, S., & Mathioudakis, N. (2017). The effect of vitamin D supplementation on glucose metabolism in type 2 diabetes mellitus: A systematic review and meta-analysis of intervention studies. Journal of diabetes and its complications, 31 7, 1115-1126 .

22) Mousa, A., Naderpoor, N., Teede, H., Scragg, R., & Courten, B. (2018). Vitamin D supplementation for improvement of chronic low‐grade inflammation in patients with type 2 diabetes: a systematic review and meta‐analysis of randomized controlled trials. Nutrition Reviews, 76, 380–394.

23) Sadek, K., & Shaheen, H. (2014). Biochemical efficacy of vitamin D in ameliorating endocrine and metabolic disorders in diabetic rats. Pharmaceutical Biology, 52, 591 - 596.

24) Hyppönen, E., Läärä, E., Reunanen, A., Järvelin, M., & Virtanen, S. (2001). Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. The Lancet, 358, 1500-1503.

25) Arnson, Y., Amital, H., & Shoenfeld, Y. (2007). Vitamin D and autoimmunity: new aetiological and therapeutic considerations. Annals of the Rheumatic Diseases, 66, 1137 - 1142.

26) Dankers, W., Colin, E., Hamburg, J., & Lubberts, E. (2017). Vitamin D in Autoimmunity: Molecular Mechanisms and Therapeutic Potential. Frontiers in Immunology, 7.

27) Mirhosseini, N., Vatanparast, H., Mazidi, M., & Kimball, S. (2018). Vitamin D Supplementation, Glycemic Control, and Insulin Resistance in Prediabetics: A Meta-Analysis. Journal of the Endocrine Society, 2, 687 - 709.

28) Karamali, M., Asemi, Z., Ahmadi-Dastjerdi, M., & Esmaillzadeh, A. (2015). Calcium plus vitamin D supplementation affects pregnancy outcomes in gestational diabetes: randomized, double-blind, placebo-controlled trial. Public Health Nutrition, 19, 156 - 163.

29) Ansari, M., Sabico, S., Clerici, M., Khattak, M., Wani, K., Al-Musharaf, S., Amer, O., Alokail, M., & Al-Daghri, N. (2020). Vitamin D Supplementation is Associated with Increased Glutathione Peroxidase-1 Levels in Arab Adults with Prediabetes. Antioxidants, 9.

30) Razzaghi, R., Pourbagheri, H., Momen-Heravi, M., Bahmani, F., Shadi, J., Soleimani, Z., & Asemi, Z. (2017). The effects of vitamin D supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial. Journal of diabetes and its complications, 31 4, 766-772 .

31) Krul-Poel, Y., Wee, M., Lips, P., & Simsek, S. (2017). The effect of vitamin D supplementation on glycaemic control in patients with type 2 diabetes mellitus: a systematic review and meta-analysis. European journal of endocrinology, 176 1, R1-R14.

32) Bhatt, S., Misra, A., Pandey, R., Upadhyay, A., Gulati, S., & Singh, N. (2020). Vitamin D Supplementation in Overweight/obese Asian Indian Women with Prediabetes Reduces Glycemic Measures and Truncal Subcutaneous Fat: A 78 Weeks Randomized Placebo-Controlled Trial (PREVENT-WIN Trial). Scientific Reports, 10.

33) Alloubani, A., Akhu-Zaheya, L., Samara, R., Abdulhafiz, I., Saleh, A., & Altowijri, A. (2019). Relationship between vitamin D deficiency, diabetes, and obesity. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 13(2), 1457-1461.‏

34) Barbarawi, M., Zayed, Y., Barbarawi, O., Bala, A., Alabdouh, A., Gakhal, I., ... & Manson, J. E. (2020). Effect of vitamin D supplementation on the incidence of diabetes mellitus. The Journal of Clinical Endocrinology & Metabolism, 105(8), 2857-2868.‏

35) Yammine, K., Hayek, F., & Assi, C. (2020). Is there an association between vitamin D and diabetic foot disease? A meta‐analysis. Wound Repair and Regeneration, 28(1), 90-96.‏

36) Lu L, Bennett DA, Millwood IY, Parish S, McCarthy MI, Mahajan A, et al. (2018) Association of vitamin D with risk of type 2 diabetes: A Mendelian randomisation study in European and Chinese adults. PLoS Med 15(5): e1002566.

37) Amraei, M., Mohamadpour, S., Sayehmiri, K., Mousavi, S. F., Shirzadpour, E., & Moayeri, A. (2018). Effects of vitamin D deficiency on incidence risk of gestational diabetes mellitus: a systematic review and meta-analysis. Frontiers in endocrinology, 9, 7.‏

38) Ehrampoush, E., Razzaz, J. M., Ghaemi, A., Shahraki, H. R., Babaei, A. E., Osati, S., & Homayounfar, R. (2021). The association of vitamin D levels and insulin resistance. Clinical nutrition ESPEN, 42, 325-332.‏

39) Kaya, T., Akçay, E. Ü., Ertürk, Z., Ergenc, H., & Tamer, A. (2018). The relationship between vitamin D deficiency and erythrocyte sedimentation rate in patients with diabetes. Turkish Journal of Medical Sciences, 48(2), 424-429.‏

40) Bhatt, S. P., Misra, A., Gulati, S., Singh, N., & Pandey, R. M. (2018). Lower vitamin D levels are associated with higher blood glucose levels in Asian Indian women with pre-diabetes: a population-based cross-sectional study in North India. BMJ Open Diabetes Research and Care, 6(1), e000501.‏

41) Mahmood, Y., Shahid, S. M., Fawad, A., Basit, A., & Azhar, A. (2018). Association of vitamin D with type 2 diabetes mellitus in Karachi, Pakistan. Int J Biol Biotechnol, 15(2), 201-205.‏
Volume 07 Issue 10 October 2024

There is an Open Access article, distributed under the term of the Creative Commons Attribution – Non Commercial 4.0 International (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/), which permits remixing, adapting and building upon the work for non-commercial use, provided the original work is properly cited.


Our Services and Policies

Authors should prepare their manuscripts according to the instructions given in the authors' guidelines. Manuscripts which do not conform to the format and style of the Journal may be returned to the authors for revision or rejected.

The Journal reserves the right to make any further formal changes and language corrections necessary in a manuscript accepted for publication so that it conforms to the formatting requirements of the Journal.

International Journal of Multidisciplinary Research and Analysis will publish 12 monthly online issues per year,IJMRA publishes articles as soon as the final copy-edited version is approved. IJMRA publishes articles and review papers of all subjects area.

Open access is a mechanism by which research outputs are distributed online, Hybrid open access journals, contain a mixture of open access articles and closed access articles.

International Journal of Multidisciplinary Research and Analysis initiate a call for research paper for Volume 07 Issue 12 (December 2024).

PUBLICATION DATES:
1) Last Date of Submission : 26 December 2024 .
2) Article published within a week.
3) Submit Article : editor@ijmra.in or Online

Why with us

International Journal of Multidisciplinary Research and Analysis is better then other journals because:-
1 : IJMRA only accepts original and high quality research and technical papers.
2 : Paper will publish immediately in current issue after registration.
3 : Authors can download their full papers at any time with digital certificate.

The Editors reserve the right to reject papers without sending them out for review.

Authors should prepare their manuscripts according to the instructions given in the authors' guidelines. Manuscripts which do not conform to the format and style of the Journal may be returned to the authors for revision or rejected. The Journal reserves the right to make any further formal changes and language corrections necessary in a manuscript accepted for publication so that it conforms to the formatting requirements of the Journal.

Indexed In
Avatar Avatar Avatar Avatar Avatar Avatar Avatar Avatar Avatar Avatar Avatar Avatar Avatar Avatar Avatar Avatar Avatar Avatar Avatar Avatar Avatar Avatar Avatar Avatar Avatar Avatar Avatar Avatar Avatar Avatar Avatar Avatar Avatar Avatar Avatar Avatar