Peymaneh Alizadeh Taheri
Department of Neonatology, Tehran University of Medical Sciences, Bahrami Children Hospital, Tehran, Iran
DOI : https://doi.org/10.47191/ijmra/v6-i9-16Google Scholar Download Pdf
ABSTRACT:
Gastroesophageal reflux (GER) is a common physiologic process in infants that often resolves with growth and maturation, while gastroesophageal reflux disease (GERD) is a serious and common referral disease in infants and neonates. The first-line treatment for both GER and GERD is conservative therapy. H2RAs and PPIs are the two basic pharmacologic agents in the treatment of GERD in pediatrics and adults. The efficacy of PPIs is higher than that of H2RAs in GERD treatment. There are controversies in the pharmacologic treatment of neonatal GERD, and performing more clinical trials to survey the effect of PPIs and H2RAs and compare them with each other is necessary in this age group. We conducted three different clinical trials to compare the efficacy and safety of ranitidine with omeprazole or lansoprazole in refractory neonatal GERD.
KEYWORDS:Neonates, Gastroesophageal reflux disease, Pharmacologic, Treatment, Comparing
REFERENCES1) Nelson SP, Chen EH, Syniar GM, and Christoffel KK. Prevalence of symptoms of gastroesophageal reflux during infancy. A pediatric practice-based survey. Pediatric Practice Research Group. Arch Pediatr Adolesc Med. 1997;151(6): 569-72. DOI: 10.1001/archpedi.1997.02170430035007.
2) Hegar B, Dewanti NR, Kadim M, Alatas S, Firmansyah A, and Vandenplas Y. Natural evolution of regurgitation in healthy infants. Acta Paediatr. 2009; 98(7): 1189-1193. DOI: 10.1111/j.1651-2227.2009.01306. x.
3) Ciciora SL, and Woodley FW. Optimizing the use of medications and other therapies in infant gastroesophageal reflux. Paediatr Drugs. 2018; 20 (6): 523–537. DOI: 10.1007/s40272-018-0311-3.
4) Rosen R, Y. Vandenplas Y, Singendonk M, Cabana M, DiLorenzo C, Gottrand F, et al. Pediatric gastroesophageal reflux clinical practice guidelines. J Pediatr Gastroenterol Nutr. 2018;66(3):516–554. DOI: 10.1097/MPG.0000000000001889.
5) Campanozzi A, Boccia G, Pensabene L, Panetta F, Marseglia A, Strisciuglio P,et al. Prevalence and natural history of gastroesophageal reflux: A pediatric prospective survey. Pediatrics 2009;123(3):779-83. DOI: 10.1542/peds.2007-3569.
6) Orenstein SR. Symptoms and reflux in infants: Infant gastroesophageal reflux questionnaire revised (I-GERQ-R)–utility for symptom tracking and diagnosis.Curr Gastroenterol Rep 2010;12(6):431-6. DOI: 10.1007/s11894-010-0140-1.
7) Jung HK. Epidemiology of gastroesophageal reflux disease in Asia: A systematic review. J Neurogastroenterol Motil. 2011;17(1):14-27. DOI: 10.5056/jnm.2011.17.1.14.
8) Dent J, El-Serag HB, Wallander MA, and Johansson S. Epidemiology of gastro-esophageal reflux disease: A systematic review. Gut. 2005; 54 (5):710-17. DOI: 10.1136/gut.2004.051821.
9) National Collaborating Centre for Women’s and Children’s Health. Gastro-esophageal reflux disease: Recognition, diagnosis and management in children and young people. National Institute for Health and Care Excellence (NICE). London (UK): Clinical Guidelines. 2015. Bookshelf ID: NBK293624
10) Ferreira CT, de Carvalho E, Sdepanian VL, de Morais MB, Vieira MC, and Silva LR. Gastroesophageal reflux disease: exaggerations, evidence and clinical practice. J Pediatr (Rio J). 2013;90(2):105- 18. http://dx.DOI.org/10.1016/j.jped.2013.05.009
11) van der Pol RJ, Smits MJ, van Wijk MP, Omari TI, Tabbers MM, and Benninga MA. Efficacy of proton-pump inhibitors in children with gastroesophageal reflux disease: A systematic review. Pediatrics. 2011;127(5):925–935. DOI: 10.1542/peds.2010-2719.
12) Winter HS. Management of gastroesophageal reflux disease in children and adolescents. In: Post TW, ed. UpToDate. Waltham, MA. Accessed on April 1, 2019.
13) Mattos ÂZ, Marchese GM, Fonseca BB, Kupski C, and Machado MB. Antisecretory treatment for pediatric gastroesophageal reflux disease - a systematic review. Arq Gastroenterol. 2017;54(4):271–280. DOI.org/10.1590/s0004-2803.201700000-42.
14) Ward RM, Kearns GL. Proton pump inhibitors in pediatrics. Mechanism of action, pharmacokinetics, pharmacogenetics, and pharmacodynamics. Pediatr Drugs. 2013;15(2):119-131. DOI: 10.1007/s40272-013-0012-x.
15) Nelson SP, Kothari S, Wu EQ, Beaulieu N, McHale JM, and Dabbous OH. Pediatric gastroesophageal reflux disease and acid-related conditions: Trends in incidence of diagnosis and acid suppression therapy. J Med Econ. 2009; 12(4):348–355. DOI: 10.3111/13696990903378680.
16) Lightdale JR, and Gremse DA. Section on Gastroenterology, Hepatology, and Nutrition. Gastroesophageal Reflux. Management guidance for the pediatrician. J Pediatrics. 2013;131(5): e1684-1695. DOI: 10.1542/peds.2013-0421.
17) Chiba N, De Gara CJ, Wilkinson JM, and Hunt RH. Speed of healing and symptom relief in grade II to IV gastroesophageal reflux disease: A meta-analysis. Gastroenterol. 1997;112(6):1798–1810. DOI: 10.1053/gast. 1997.v112.pm9178669.
18) Barron JJ, Tan H, Spalding J, Bakst AW, and Singer J. Proton pump inhibitor utilization patterns in infants. J Pediatr Gastroenterol Nutr. 2007;4: 421–427. DOI: 10.1097/MPG.0b013e31812e0149.
19) Zhou Y , Xu L , Wushouer H , Yu A , Xu Z, Chen C, et al. Acid suppression use among infants in one tertiary children's hospital in China, 2015-2018: A retrospective observational study. Front Pediatr. 2021; 21(9):679203. DOI: 10.3389/fped.2021.679203. eCollection 2021.
20) Murthy P, Dosani A, and Lodha A. Acid suppression in neonates: Friend or Foe? 2019.Indian Pediatr. 56(15):541-546.
21) Chabra S, and Peeples ES. Assessment and management of gastroesophageal reflux in the newborn. Pediatr Ann. 2020;49(2): e77–e81. DOI: 10.3928/19382359-20200121-02.
22) Hassall E. Step-up and step-down approaches to the treatment of gastroesophageal reflux disease in children. Curr Gastroenterol Rep. 2008; 10(3): 324–331. DOI: 10.1007/s11894-008-0063-2.
23) Leung AKC, and Hon KL: Gastroesophageal reflux in children: An updated review. Drugs Context.2019; 8: 1-12. DOI: 10.7573/dic.212591. eCollection 2019.
24) Orenstein SR. Infant GERD. Symptoms, reflux episodes & reflux disease, acid & non-acid reflux- implications for treatment with PPIs. Curr Gastroenterol. Rep. 2013;15(11):353. DOI: 10.1007/s11894-013-0353-1.
25) US Food and Drug Administration: Metoclopramide-containing drugs. November 2013, http://www.fda.gov/Safety/MedWatch/SafetyInformation/Safety Alerts for Human Medical Products/ucm106942.htm, date of publication: 2009, last access: November 7, 2013.
26) Djeddi D, Kongolo G, Lefaix C, Mounard J, and Léké A: Effect of domperidone on QT interval in neonates. J Pediatr. 2008; 153(5): 663–666. DOI: 10.1016/j.jpeds.2008.05.013.
27) Zamora SA, Belli DC, Ferrazzini G, and Friedli B. Effects of cisapride on ventricular depolarization-repolarization and arrhythmia markers in infants. Neonatol. 2001; 80(1) :30–34. DOI: 10.1159/000047116.
28) Albert RK, Schuller JL, and COPD Clinical Research Network. Macrolide antibiotics and the risk of cardiac arrhythmias. Am J Respir Crit Care Med.2014;189(10): 1173–1180. DOI: 10.1164/rccm.201402-0385CI.
29) Taheri PA, Mahdianzadeh F, Shariat M, and Sadeghi M. Combined therapy in gastroesophageal reflux disease of term neonates, refractory to conservative therapy and monotherapy: A clinical trial. JPNIM.2018;79(2): e070201.
30) Sajjadian N, Akhavan Z, Taheri PA, and Shariat M. A new therapeutic strategy for gastroesophageal reflux disease refractory to conservative therapy and monotherapy in preterm neonates: A clinical trial. JPNIM. 2019;8(1): e080125.
31) Taheri PA, Validad E, and Eftekhari K. The safety and efficacy of lansoprazole plus metoclopramide among neonates with gastroesophageal reflux disease refractory to conservative therapy and monotherapy: A clinical trial.2021: Int J Pediatr.2021. Article ID 3208495, 9 pages https://DOI.org/10.1155/2021/3208495.
Volume 06 Issue 09 September 2023
There is an Open Access article, distributed under the term of the Creative Commons Attribution – Non Commercial 4.0 International (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/), which permits remixing, adapting and building upon the work for non-commercial use, provided the original work is properly cited.
Our Services and Policies
Authors should prepare their manuscripts according to the instructions given in the authors' guidelines. Manuscripts which do not conform to the format and style of the Journal may be returned to the authors for revision or rejected.
The Journal reserves the right to make any further formal changes and language corrections necessary in a manuscript accepted for publication so that it conforms to the formatting requirements of the Journal.
International Journal of Multidisciplinary Research and Analysis will publish 12 monthly online issues per year,IJMRA publishes articles as soon as the final copy-edited version is approved. IJMRA publishes articles and review papers of all subjects area.
Open access is a mechanism by which research outputs are distributed online, Hybrid open access journals, contain a mixture of open access articles and closed access articles.
International Journal of Multidisciplinary Research and Analysis initiate a call for research paper for Volume 07 Issue 12 (December 2024).
PUBLICATION DATES:
1) Last Date of Submission : 26 December 2024 .
2) Article published within a week.
3) Submit Article : editor@ijmra.in or Online
Why with us
1 : IJMRA only accepts original and high quality research and technical papers.
2 : Paper will publish immediately in current issue after registration.
3 : Authors can download their full papers at any time with digital certificate.
The Editors reserve the right to reject papers without sending them out for review.
Authors should prepare their manuscripts according to the instructions given in the authors' guidelines. Manuscripts which do not conform to the format and style of the Journal may be returned to the authors for revision or rejected. The Journal reserves the right to make any further formal changes and language corrections necessary in a manuscript accepted for publication so that it conforms to the formatting requirements of the Journal.