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VOLUME 04 ISSUE 05 MAY 2021

Role of GPR109A Receptor in the Efficacy of Nicotinic Acid
1Virendra Tangri, 2Ashok Kumar, 3Anurag Prakash S, 4Neeraj Kumar, 5Bhupinder singh
1,2DIT University -Department of Pharmacy, Dehradun, Uttarakhand
3,4Department of Pharmacy, Maya College of Pharmacy, Dehradun, Uttarakhand
5Global institute of pharmaceutical education & research, Uttarakhand
DOI : https://doi.org/10.47191/ijmra/v4-i5-21

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ABSTRACT:

Nicotinic acid is used to treat dyslipidemia from the past few decades. Nicotinic acid has the capability to increase plasma HDL cholesterol concentration, and so it is being used as a potential pharmacological agent. Nicotinic acid has an unwanted side effect called flushing, which effect the patients compliance as this is unpleasant . With the help of receptor GPR109A for nicotinic acid it is possible to understand the underlying mechanism of action and effects of nicotinic acid, and this helped in maximizing the potential pharmacological effects of nicotinic acid and reducing the flushing side effects.GPR109A is a G protein coupled receptor which is activated by nicotinic acid (NA).The role of GPR109A receptor in the efficacy of nicotinic acid is discussed in this paper.

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VOLUME 04 ISSUE 05 MAY 2021

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