¹,²Ogbu, Innocent S. I.,² Ikpeama Anthony I.,¹ Ogbu, Chinemerem C.,
¹ Nwobodo, Emmanuel I., ³Odochi, Ogbu C.,⁴ Nduka, Okeke J.

¹Department of Medical Laboratory Science, Evangel University Akaeze. Ebonyi State. Nigeria

²Department of Medical Laboratory Science, University of Nigeria, Enugu Campus. Enugu Nigeria

³Department of Physiology, Evangel University Akaeze. Ebonyi State. Nigeria

⁴Department of Chemical Pathology, Faculty of Clinical Medicine. Ebonyi State University. Abakaliki. Ebonyi State. Nigeria

Aim:
Fasting plasma glucose (FPG) is the concentration of plasma glucose after an overnight (≤ 8 hours) fast. It is diagnostic of diabetes mellitus and prediabetes. It is used in the screening of other health conditions and monitoring of treatment of diabetes. It is useful to determine factors that influence FPC for more accurate interpretation of the test.
Procedure:
One hundred and fifty (150) apparently healthy subjects aged 1 – 80 years were recruited for the study after an informed consent. Their ages were noted, weight and height measured and body mass index (BMI) calculated. Two milliliters of fasting blood sample were collected from each before 10 am each day and put into fluoride-oxalate bottle. The samples were spun and the plasma analyzed for glucose on the same day using the Glucose oxidase method.
Results:
The range of FPG values obtained was 2.3 – 7.0mmol/l and mean age, BMI, and FPG, (±SD), were 38.25 ±21.86 years, 26.49 ±6.37 and 4.23 ±0.96mmol/l respectively. FPG correlated with age (r 2 = 0.4469; p=0.0001) and BMI (r 2 =0.2271; p=0.0001). FPG differed with age and BMI. 98% of the subjects had FPG within the range 2.2 - 6.6 mmol/l with 72% falling within the range 3.4 – 5.5mmol/l. There was no significant difference between the male and female values though this existed in their BMI, (p=0.0178).
Conclusion:
FPG is influenced by both age and BMI of subjects, there is, therefore, the need to take these factors into consideration in the interpretation of results of FPG tests.

Fasting plasma glucose; body weight; age; body mass index.

1) Woolf, Z.a; Smith, A. Fasting blood glucse; Diabetes mellitus, types 2, 1; treatment: 3393. https://www.medterms.com

2) Ratini, M. Fasting blood glucose; Discovery Health; articlekey =3472; https://www.discovery.com

3) Juet, D.M Schole A.E. Glucose test; medlineplus. Medical encyclopaedia; 003482; http://www.nlm.nih.gov

4) Dacie, J.V; Lewis, S.M;. Practical Haematology(1 - 20). 5th Edition ELBS and Churchill Livingstone. P. 1- 20, 1975.

5) Trinder, P. Glucose enzyme (GOD/POD) method. Ann of Clin Biochem. 1969 6:24 – 27.

6) Bakari AG, Onygemelukwe GC, Sani BG, Aliyu IS, Hassan SS, Aliyu TM. Relationship between random blood sugar and body mass index in an African population. Int J Diabetes Metab. 2006; 14:144–5.

7) Panagiotakos DB, Pitsavos C, Chrysohoou C, Risvas G, Kontogianni MD, Zampelas A, et al. Epidemiology of overweight and obesity in a Greek adult population: the ATTICA Study. Obes Res. 2004; 12:1914–20.

8) McGee Dl. Diverse Population Collaboration. Body mass index and mortality; a meta-analysis based on person-level data from twenty-six observational studies. Ann Epidemiol. 2005; 15:87–97.

9) Kragelund C, Hassager C, Hildebrandt P, Torp-Pedersen C, Kober L. Impact of obesity on long-term prognosis following acute myocardial infarction. Int J Cardiol. 2005; 98:123–31.

10) Onyesom Innocent1†, Oweh O ThankGod1†, Etumah O Sandra2† and Ifie E Josiah1* Correlation between body mass index and blood glucose levels among some Nigerian undergraduates. Herbert Open Access J. Biol; 2013 2:4 DOI: http://dx.doi.org/10.7243/2050-0874-2-4

11) Md. Imam Hossain, Md. Shariful Islam, Mirza Rokibul Hasan, Moriom Akter, Md.Sadek Hosen Khoka. Fasting blood glucose level and its association with sex, body mass index and blood pressure: a cross sectional study on a Bangladeshi public university studentsIntl J. of Comm Med.Pub.Health | 2017 August l; 4(8):2663-26699 http://www.ijcmph.compISSN2394- 6032

12) Slimane Mehdad, Abdeslam Hamrani, Khalid El Kari, Asmaa El Hamdouchi, Amina Barakat, Mohamed El Mzibri, Najat Mokhtar, and Hassan Aguenaou. Body Mass Index, Waist Circumference, Body Fat, Fasting Blood Glucose in a Sample of Moroccan Adolescents Aged 11–17 Years. J. Nutri Meta., 2012, Article ID 510458, 7 pages, 2012. https://doi.org/10.1155/2012/510458

13) Ibrahim, M. Interpretation of FBG values. Pan Arab Conference of Diabetes. Vol1(1)

14) Cheesbrough, M. Medical Laboratory Manual for Tropical Countries vol. 1; 2nd edition: University Press, Britain. P110 - 125

15) Willet, M.C; Manson, J.E; Stampfer, M.J;, Colditz, G.A; Rosner, B; Speizer, C.H; Hennekens, C.H; (1995). Weight, weight change and coronary heart disease in women: risk within the ‘normal’ weight range. JAMA 273: 461 – 465.

16) Colditz, G.A; Willet, W.C; Rotnitzky, A; Manson, J.E; (1995). Weight gain as a risk factor for clinical diabetes mellitus in women. Ann Intern Med. 122: 481 – 486.

17) Huang, Z; Willet, W.C; Manson J.E; Rosner, B; Stampfer, M.J; Speizer, F.E; Colditz, G.A; (1998). Body weight, weight change and the risk of hypertension in women. Ann Intern Med. 128 (1): 81 – 88.

18) Maclure, K.M; Hayes, K.C; Colditz, G.A; Stampfer, M.J; Speizer, F.E; Willet. W.C; (1989). Weight, diet and risk of symptomatic gallstone in middle aged women. New Engl J. Med 321 (9): 563 – 569.

19) Nesto, R; (2004). C-reactive protein: its role in inflammation, type 2 diabetes and cardiovascular disease and the effect of insulin-sensitizing treatment with thiazolidinediones. Diab Med 21: 810 – 817.

20) Bays, H; Mandrino, L; Defronzo, R.A; (2004). Role of the adipocyte, free fatty acid and ectopic fat in the pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach. J Clin Endocrinol Metab 89: 463 – 478.

21) Hseuh, W.A; Lyon, C.J; Quinones, M.J; (2004). Insulin resistance and the endothelium. Am J Med. 117 (1): 109 – 117.

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