• editor@ijmra.in
  • ISSN[Online] : 2643-9875  ||  ISSN[Print] : 2643-9840

VOLUME 02 ISSUE 02 NOVEMBER 2019

Do we Need Prophylactic Salphingectomy for Ovary Preserving in Hysterectomy.
1Eddy Hartono
1Department of Obstetrics and Gynecology, Hasanuddin University, Makassar, South Sulawesi, Indonesia Elected International Society for Gynecological Endoscopy (ISGE) Board Member 2017-2021
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ABSTRACT

Ovarian carcinoma was believed to had arised from fallopian tubes and then spread to ovarian surface and peritoneum. In addition, Lack of ovarian lesion precursor identified and the fact that bilateral salphingo-Oopherectomy performed to protect women with BRCA mutations from ovarian carcinoma lead many authors postulated that fallopian tube is probably the origin of serous ovarian carcinoma. Lately, initial form of serous carcinoma in fallopian tubes of women with BRCA mutation has been identified and this precursor lesion is known as STIC (serous tubal intraepitelial carcinoma).Prophylactic BSO in high risk women (with BRCA mutation) after completed parity may reduce risk of ovarian carcinoma dramatically (80%). Meanwhile, prophylactic salpingectomy as an alternative may suffice to prevent ovarian carcinoma if we could ensure that serous ovarian carcinoma arise from tubal fimbriae.

KEY-WORDS

ovarian carcinoma, BRCA, STIC, salpingo-Oopherectomy, salpingectomy

REFERENCES

1) BACKES, F. J. 2014. Salpingectomy, why not? American Journal of Obstetrics & Gynecology.

2) COLEMAN, R. L. 2012. Origins of Ovarian Cancer: Endometriosis? M. D. Anderson Cancer Center.

3) COLGAN, T. J. 2003. Challenges in the Early Diagnosis and Staging of Fallopian-Tube Carcinomas Associated with BRCA Mutations. International Journal of Gynecological Pathology, 22, 109–120.

4) ERICKSON, B. K., JR, C. N. L. & CONNER, M. G. 2013. Risk-reducing salpingectomy as a new and safe strategy to prevent ovarian cancer. American Journal of Obstetrics & Gynecology, 396.

5) HICKEY, M., AMBEKAR, M. & HAMMOND, I. 2010. Should the ovaries be removed or retained at the time of hysterectomy for benign disease? Human Reproduction Update, 16, 131-141.

6) KURMAN, R. J. & SHIH, I.-M. 2010. The Origin and Pathogenesis of Epithelial Ovarian Cancer: A Proposed Unifying Theory. Am J Surg Pathol, 34.

7) LI, J., FADARE, O., XIANG, L., KONG, B. & ZHENG, W. 2012. Ovarian serous carcinoma: recent concepts on its origin and carcinogenesis. Journal of Hematology & Oncology, 5.

8) MCALPINE, J. N., HANLEY, G. E., WOO, M. M. M., TONE, A. A., ROZENBERG, N., SWENERTON, K. D., GILKS, C. B., FINLAYSON, S. J., HUNTSMAN, D. G. & MILLER, D. M. 2014. Opportunistic salpingectomy: uptake, risks, and complications of a regional initiative for ovarian cancer prevention. Am J Obstet Gynecol, 210.

9) MINGELS, M., ROELOFSEN, T., LAAK, J. V. D., HULLU, J. A. D., HAM, M. V., MASSUGER, L., BULTEN, J. & BOL, M. 2012. Tubal epithelial lesions in salpingo-oophorectomy specimens pf BRCA-mutation carriers and controls. Gynecol Oncol, 127, 88-93.

10) NAROD, S. A. 2013. Salpingectomy to prevent ovarian cancer A Countercurrents Series. Current Oncology, 20.

11) ROELOFSEN, T. 2013. Towards a better understanding of serous carcinoma of the female genital tract. The Netherlands.

12) TANNER, E. J., LONG, K. C., VISVANATHAN, K. & FADER, A. N. 2013. Prophylactic salpingectomy in premenopausal women at low risk for ovarian cancer: risk-reducing or risky? Fertility and Sterility, 100.

VOLUME 02 ISSUE 02 NOVEMBER 2019

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